Nk Cell Based Cancer Immunotherapy

Natural killer nk cells are innate immune cells endowed with potent cytolytic activity against tumors and meanwhile act as regulatory cells for the immune system.

Nk cell based cancer immunotherapy.

Natural killer nk cells can induce an antigen independent immune response against malignant cells. A new cell based immunotherapy for some types of blood cancer has posted promising initial results in a small clinical trial on patients who had exhausted all other treatment options. Cancer immunotherapy has been firmly established as a new milestone for cancer therapy with the development of multiple immune cells as therapeutic tools. In this review we provide a summary of the mechanisms of tumor escape from nk cell recognition the current status and advanced progress of nk cell based immunotherapy strategies to enhance the efficacy of nk cells in vivo and major challenges for clinical practice in this.

Authors raquel tarazona 1. A growing number of scientific reports and clinical studies have shown promising anti tumor effects when using nk cell based immunotherapy. Natural killer nk cells can induce an antigen independent immune response against malignant cells. Currently various approaches are being used to enhance the number and function of nk cells.

Currently various approaches are being used to enhance the number and function of nk cells. Epub 2020 mar 4. Cambridge healthtech institute s 3rd annual nk cell based cancer immunotherapy conference will once again convene immuno oncology researchers cancer immunotherapy developers and technology providers to discuss current challenges and opportunities from discovery nk immuno oncology to clinical studies share latest technologies and. Indeed nk cell based immunotherapy is becoming a promising approach for the treatment of many cancers.

All the accumulated knowledge on nk cell biology along with many clinical observations is driving multiple efforts to improve the arsenal of nk cell based therapeutic tools in the fight against malignant diseases. The efficacy of nk cell mediated immunotherapy can be enhanced by immune. It is well known that nk.